This presentation highlights Fire Safety Research Institute’s (FSRI’s) recent research on characterizing smoke from vehicle fires. It is well known that firefighting activities can expose firefighters to many occupational hazards and those exposures are associated with long-term health risks including cancer. Fires involving lithium-ion batteries in vehicles have garnered the attention of the fire service due to the challenges faced in suppressing the fires and some of the unique characteristics of the smoke produced. As the fire service responds to more fires involving lithium-ion batteries, much is left to learn about the contamination produced by these fires including what is in the surrounding air during these incidents, what gets on firefighters’ PPE, and what firefighters and fire departments can do to mitigate these risks. To mitigate exposure risks, the fire service has been engaged in a wide range of activities focused on the development, testing, and implementation of effective approaches to reduce exposure to contaminants and the related cancer risk. To support fire departments’ decision making around implementing feasible and effective control solutions, we will introduce fire service contamination control in the context of the National Institute for Occupational Safety and Health Hierarchy of Controls framework. Measures that will be discussed include personal protective equipment, administrative, engineering, substitution, and elimination controls. Using this approach, we will discuss evidence-based measures that have been investigated and that can be implemented to protect firefighters during an emergency response, in the fire apparatus, and at the fire station.